File Associations in Windows 7 can sometimes just stop working. This can occur after a software or Windows Update. Sometimes even upgrades can cause files to just not open. This issue is especially common with Microsoft Office file associations like doc, docx, xls, xlsx, ppt, pptx, pps, ppsx to name a few. To resolve follow the simple steps below: - Click Start and then Run Type regedit and click Ok (This opens the registry editor) Navigate to Computer\HKEY_CLASSES_ROOT\Applications and find your .exe name For example purposes I have browsed to EXCEL (See pic below) Expand EXCEL -> shell -> open -> command (See pic below) 
- In the right hand pane double click the (Default) string and change the path to the location of the actual executable (Microsoft Excel in this case) 
- Click OK and close Registry Editor
- Now simply reassociate the file type as you normally would.
The simplest way of doing this is to right-click file and click Open With
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